Connectome sensitivity or specificity: which is more important?

A Zalesky; A Fornito; L Cocchi; LL Gollo; MP van den Heuvel; M Breakspear

Journal article

Connectome sensitivity or specificity: which is more important?

A Zalesky, A Fornito, L Cocchi, LL Gollo, MP van den Heuvel, M Breakspear

Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016

DOI: 10.1016/j.neuroimage.2016.06.035

Abstract

Connectomes with high sensitivity and high specificity are unattainable with current axonal fiber reconstruction methods, particularly at the macro-scale afforded by magnetic resonance imaging. Tensor-guided deterministic tractography yields sparse connectomes that are incomplete and contain false negatives (FNs), whereas probabilistic methods steered by crossing-fiber models yield dense connectomes, often with low specificity due to false positives (FPs). Densely reconstructed probabilistic connectomes are typically thresholded to improve specificity at the cost of a reduction in sensitivity. What is the optimal tradeoff between connectome sensitivity and specificity? We show empirically an..

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University of Melbourne Researchers

Andrew Zalesky Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

A.Z., A.F., L.C., L.L.H and M.B. are supported by the Australian National Health and Medical Research Council (grant identifiers: 1050504, 1066779, 1047648, 1037196, 1103252 and 1099082) and the Australian Research Council (ID: FT130100589, CE140100007). M.P.vdH. is supported by a VENI (451-12-001) grant from the Netherlands Organization for Scientific Research and a fellowship from MQ.